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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADA All Species: 16.67
Human Site: Y351 Identified Species: 33.33
UniProt: P00813 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P00813 NP_000013.2 363 40764 Y351 L D L L Y K A Y G M P P S A S
Chimpanzee Pan troglodytes XP_001144517 363 40678 Y351 L D L L Y K A Y G M P P S A S
Rhesus Macaque Macaca mulatta XP_001109908 572 62188 Y560 L D L L Y K A Y G M P P P A S
Dog Lupus familis XP_534428 362 41003 Y350 L D L L Y K A Y G M P S L D A
Cat Felis silvestris
Mouse Mus musculus P03958 352 39973 K341 F L P E E E K K E L L E R L Y
Rat Rattus norvegicus Q920P6 352 39881 K341 F L P E D E K K E L L E R L Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508594 308 34510 G297 W R E E K A Q G P E A A R N P
Chicken Gallus gallus Q5ZKP6 357 40660 N344 K E K Q E L L N T L Y E A Y G
Frog Xenopus laevis Q6GP70 358 40658 Y347 K E L L Y K L Y E A Y G M I L
Zebra Danio Brachydanio rerio Q6DG22 359 40825 Y348 E K L L N Q L Y E A Y G M R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_501087 391 43657 C369 Q L N A A R S C F L P E D E K
Sea Urchin Strong. purpuratus XP_785367 391 43729 S380 L P D K E K T S L V K E L Q A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 61.3 85.6 N.A. 80.9 83.1 N.A. 58.9 65.5 69.1 64.1 N.A. N.A. N.A. 31.4 35.8
Protein Similarity: 100 99.4 62.7 91.4 N.A. 90.6 91.4 N.A. 68.3 79 81.8 78.5 N.A. N.A. N.A. 50.3 54.4
P-Site Identity: 100 100 93.3 73.3 N.A. 0 0 N.A. 0 0 33.3 20 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 100 93.3 80 N.A. 13.3 13.3 N.A. 0 20 40 26.6 N.A. N.A. N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 9 9 34 0 0 17 9 9 9 25 17 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 34 9 0 9 0 0 0 0 0 0 0 9 9 0 % D
% Glu: 9 17 9 25 25 17 0 0 34 9 0 42 0 9 0 % E
% Phe: 17 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 9 34 0 0 17 0 0 9 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % I
% Lys: 17 9 9 9 9 50 17 17 0 0 9 0 0 0 17 % K
% Leu: 42 25 50 50 0 9 25 0 9 34 17 0 17 17 9 % L
% Met: 0 0 0 0 0 0 0 0 0 34 0 0 17 0 0 % M
% Asn: 0 0 9 0 9 0 0 9 0 0 0 0 0 9 0 % N
% Pro: 0 9 17 0 0 0 0 0 9 0 42 25 9 0 9 % P
% Gln: 9 0 0 9 0 9 9 0 0 0 0 0 0 9 0 % Q
% Arg: 0 9 0 0 0 9 0 0 0 0 0 0 25 9 0 % R
% Ser: 0 0 0 0 0 0 9 9 0 0 0 9 17 0 25 % S
% Thr: 0 0 0 0 0 0 9 0 9 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 42 0 0 50 0 0 25 0 0 9 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _